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Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1gene.[5][6]
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.[7]
^Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID16470849. S2CID40041491.
Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID11071307. S2CID28762005.
Loewen ME, Bekar LK, Gabriel SE, et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. 298 (4): 531–6. doi:10.1016/S0006-291X(02)02498-1. PMID12408984.
Zhou Y, Shapiro M, Dong Q, et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–65, discussion 165–70, 277–82. doi:10.1002/0470860790.ch10. ISBN9780470844786. PMID12568493.
Ritzka M, Stanke F, Jansen S, et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID15490240. S2CID12935280.
Jeong SM, Park HK, Yoon IS, et al. (2005). "Cloning and expression of Ca2+-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. 334 (2): 569–76. doi:10.1016/j.bbrc.2005.06.122. PMID16023076.