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ER-X

From Wikipedia, the free encyclopedia

Not to be confused with ERx.

ER-X is a membrane-associated receptor that is bound and activated by 17α-estradiol and 17β-estradiol and is a putative membrane estrogen receptor (mER).[1][2][3] It shows sequence homology with ERα and ERβ and activates the MAPK/ERK pathway.[3] The receptor is insensitive to the antiestrogen ICI-182,780 (fulvestrant).[3]

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Transcription

See also

References

  1. ^ Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, et al. (October 2002). "ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury". The Journal of Neuroscience. 22 (19): 8391–8401. doi:10.1523/JNEUROSCI.22-19-08391.2002. PMC 6757764. PMID 12351713.
  2. ^ Soltysik K, Czekaj P (April 2013). "Membrane estrogen receptors - is it an alternative way of estrogen action?". Journal of Physiology and Pharmacology. 64 (2): 129–142. PMID 23756388.
  3. ^ a b c Roepke TA, Ronnekleiv OK, Kelly MJ (January 2011). "Physiological consequences of membrane-initiated estrogen signaling in the brain". Frontiers in Bioscience. 16 (4): 1560–1573. doi:10.2741/3805. PMC 3094271. PMID 21196248.
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This page was last edited on 2 November 2023, at 06:31
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