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ERx

From Wikipedia, the free encyclopedia

Not to be confused with ER-X.

ERx is a putative membrane estrogen receptor (mER) of which little is currently known.[1][2] It was discovered as a gene transcription signature induced by estradiol that is independent of the ERα/ERβ and GPER and was identified using the membrane-impermeable estradiol conjugate E2-BSA in the absence or presence of the ERα/ERβ antagonist fulvestrant (ICI-182,780) and the GPER antagonist G-15.[1][2]

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Transcription

See also

References

  1. ^ a b Kampa M, Notas G, Pelekanou V, Troullinaki M, Andrianaki M, Azariadis K, et al. (August 2012). "Early membrane initiated transcriptional effects of estrogens in breast cancer cells: First pharmacological evidence for a novel membrane estrogen receptor element (ERx)". Steroids. 77 (10): 959–967. doi:10.1016/j.steroids.2012.02.011. PMID 22406407. S2CID 21837495.
  2. ^ a b Soltysik K, Czekaj P (April 2013). "Membrane estrogen receptors - is it an alternative way of estrogen action?". Journal of Physiology and Pharmacology. 64 (2): 129–142. PMID 23756388.
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This page was last edited on 2 November 2023, at 06:32
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